Federer is competing at the French Open for the first time sine 2015 and he has been drawn against Lorenzo Sonego in the opening round.
He will then take on Malek Jaziri or a qualifier in the second round.
The Swiss star has been drawn in the same half as 11-time champion Nadal, who will take on a qualifier in both of his opening two rounds.
World No 1 Djokovic opens against Hubert Hukacz.
French Open projected quarter-finals
Novak Djokovic vs Alexander Zverev
Dominic Thiem vs Juan Martin del Potro
Stefanos Tsitsipas vs Roger Federer
Kei Nishikori vs Rafael Nadal
French Open projected third-round matches
Shapovalov vs Coric
Wawrinka vs Cilic
Schwartzman vs Cecchinato
De Minaur vs Medvedev
Pella vs Basilashvili
Lajovic vs Zverev
Edmund vs Thiem
Monfils vs Verdasco
Auger Aliassime vs Verdasco
Tsitsipas vs Tiafoe
Berrettini vs Federer
Goffin vs Nadal
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