Carl Frampton announced his retirement after failing in his bid to become Ireland's first three-weight world champion.
Frampton was looking to create history in Dubai against Jamel Herring but was stopped in the sixth round.
Herring made the better start and dropped his challenger in the fifth session before the towel was thrown in the next session to signal the end of the Northern Irishman's illustrious career.
"I'm deeply upset. I wanted to dedicate this victory to [amateur coach] Billy McKee," said Frampton. "I said I would retire if I lost this fight and that's what I'm going to do.
“I want to dedicate the rest of my life to my family now. I want to dedicate my life to them now. Boxing has been great to me, but it has also been bad to me.”
A former super-bantamweight and featherweight world champion, Frampton was bidding to add Herring's super-featherweight strap to his burgeoning collection.
Herring won his belt by outpointing Masayuki Ito in 2019 and followed that up with successful defences against first Lamont Roach and last year against Jonathan Oquendo who was disqualified for deliberate headbutts.
And with a significant seven-inch reach advantage, the champion took the centre of the ring and looked to utilise his jab from the opening bell.
And Herring also edged the second round as he caught Frampton with the left hook as his challenger looked to close the distance.
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Frampton landed his best shot in the third session with a left hand which forced the champion back on to the ropes.
Herring was forced back again in the fourth and was left with a cut over his right eye as Frampton smelled blood.
But the champion showed little sign of being discouraged and he dropped Frampton with a straight left hand in the next stanza.
And he repeated the trick in the sixth round, this time with a left uppercut. Frampton beat the count but was saved by his corner seconds later.
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