Fabinho was taken off for Liverpool after just 28 minutes of their Champions League group stage game against Midtjylland as the Reds' injury crisis continues.
The Brazilian pulled up with what looked like a hamstring problem and was immediately replaced by 19-year-old Rhys Williams.
It comes after Virgil van Dijk was ruled out for possibly the rest of the season with an ACL injury sustained against Everton earlier this month.
Joel Matip is also currently missing for the Reds, meaning Joe Gomez is the only natural senior centre-back at the club still fit.
And there are even more worries after Jordan Henderson was replaced by Gini Wijnaldum at half-time.
The midfielder did take a heavy knock in the first-half, but it is not yet clear whether or not he is actually injured or if he was just taken off as a precaution.
It was a relatively low-key start to the game at Anfield, with Liverpool struggling to create many chances against a vastly inferior Midtjylland team.
It was the hosts who went closest to opening the scoring after just three minutes when Ander Dreyer was put through on goal and forced Alisson into a smart save.
But regardless of the result Liverpool's night may well be soured by the injury to Fabinho, with their options at centre-back running out.
His replacement Williams has limited experience at the top level, making just two Carabao Cup appearances and one brief cameo when he came on in the dying stages against Ajax last week.
Prior to tonight's game Fabinho had received praise from goalkeeper Alisson for the way he has adapted to changing from his natural defensive midfield role to centre-back in Van Dijk's absence.
Speaking about his performance in the weekend's 2-1 win over Sheffield United, Alisson said: "Fab is a fantastic player, he is doing really well as a centre-back.
"We will miss Virgil a lot, we can’t deny that. But we have the players we need to keep playing our way and to keep doing our best.
"We don’t need to change the way we play, but we will miss him. He is one of the best players in the world and when you don’t have those players on the pitch, you will miss them. That’s a fact."
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